Ubaldo Jimenez (3-3) lost for the first time in four starts this year at Camden Yards, thanks in part to home runs by Mike Trout and David Freese.
Chris Tillman has been scratched from Sunday's start due to back stiffness.
The Orioles sent infielder Jayson Nix, who had been playing for Norfolk, to the Philadelphia Phillies for cash considerations.
Ubaldo Jimenez steps in for the ailing Bud Norris as the Orioles face the Los Angeles Angels.
Wei-Yin Chen pitched well, but the Orioles offense was held in check by Jered Weaver in a 3-1 loss to the Los Angeles Angels.